Structural brain changes with lifetime trauma and re-experiencing symptoms is 5-HTTLPR genotype-dependent
نویسندگان
چکیده
منابع مشابه
War exposure, 5-HTTLPR genotype and lifetime risk of depression.
BACKGROUND In 1962 approximately 1.5 million French people living in Algeria were repatriated to France in very poor and often life-threatening conditions. These people constitute a cohort for the study of the long-term impact of gene-environment interaction on depression. AIMS To examine the interaction between a highly stressful life event and subsequent depression, and its modulation by a ...
متن کاملSerotonin Transporter (5-HTTLPR) Genotype and Childhood Trauma are Associated with Individual Differences in Decision Making
The factors that influence individual differences in decision making are not yet fully characterized, but convergent evidence is accumulating that implicates serotonin (5-HT) system function. Therefore, both genes and environments that influence serotonin function are good candidates for association with risky decision making. In the present study we examined associations between common polymor...
متن کاملWar exposure , 5 - HTTLPR genotype and lifetime risk of depression ARTERO
In 1962 approximately 1.5 million French people living in Algeria were repatriated to France in very poor and often life-threatening conditions. These people constitute a cohort for the study of the long-term impact of gene-environment interaction on depression. ARTERO, Sylvaine, et al. War exposure, 5-HTTLPR genotype and lifetime risk of depression. British Journal of Psychiatry, 2011, vol. 19...
متن کاملThreat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism.
Communication between the amygdala and other brain regions critically regulates sensitivity to threat, which has been associated with risk for mood and affective disorders. The extent to which these neural pathways are genetically determined or correlate with risk-related personality measures is not fully understood. Using functional magnetic resonance imaging, we evaluated independent and inte...
متن کامل5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation.
Amygdala reactivity is a heritable trait, potentiated in affective disorders and associated with both the 5-HTTLPR and the COMTval158met polymorphism. Fifty-four healthy volunteers selected a priori based on gender and 5-HTTLPR/rs25531 and COMTval158met genotypes performed a passive viewing task of angry facial expressions using fMRI. Amygdala reactivity and habituation were investigated using ...
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ژورنال
عنوان ژورنال: European Journal of Psychotraumatology
سال: 2020
ISSN: 2000-8198,2000-8066
DOI: 10.1080/20008198.2020.1733247